Log in
|
Help
|
English

English

Engish-Pirate

한국어

Search

Advanced Search

Find results with:

Add another field

Search by date

to

Searching collections:

Tulane University Theses and Dissertations Archive

Add or remove collections

Home Model selection and optimization of the sodium ion channel through the use of single and ensemble...

Reference URL

Share

Add tags

Comment

Rate

To link to this object, paste this link in email, IM or document

To embed this object, paste this HTML in website

Model selection and optimization of the sodium ion channel through the use of single and ensemble pulse protocols

View Description

small (250x250 max)

medium (500x500 max)

large ( > 500x500)

Full Resolution

There is no file associated with this item.

you wish to report:

Your comment:

Your Name:

Submit

Cancel

...

Back to top

Powered by CONTENTdm®

Select the collections to add or remove from your search

A

B

C

D

E

F

G

H

I

J

K

L

M

N

O

P

Q

R

S

T

U

V

W

X

Y

Z

Select All Collections

OK

Cancel

Disclaimer	Access requires a license to the Dissertations and Theses (ProQuest) database.
Link to File	http://libproxy.tulane.edu:2048/login?url=http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3089363
Title	Model selection and optimization of the sodium ion channel through the use of single and ensemble pulse protocols
Author	Hosein-Sooklal, Azida
School	Tulane University
Academic Field	Biophysics, General
Abstract	Nonequilibrium Response Spectroscopy (NRS), the technique of using rapidly fluctuating voltage pulses in the study of ion channels is applied here. NRS is known to drive an ensemble of ion channels far from equilibrium where it has been argued that new details of ion channel kinetics can be studied under nonequilibrium conditions. In this study, single pulse NRS technique with custom designed waveforms built from wavelets are used. Two series of experiments were implemented using custom designed pulses, which were obtained using a pulse search algorithm with suitable 'cost functionals' as constraints in the design of the pulse. The use of NRS pulses in model selection was investigated, as well as an in the analysis of model topology through parametric optimization. Electrophysiological recordings (whole cell ionic current measurements) were made from mammalian cells (HEK 293) which stably expressed the sodium ion channel. Wavelet analysis of the model response and the experimental data is introduced. Its effectiveness in the data analysis is demonstrated in the unique plots of the wavelet transforms. The results show how these new NRS pulses can be applied in a systematic way to study ion channels gating kinetics
Language	eng
Advisor(s)	Kargol, Armin
Degree Date	2003
Degree	Ph.D
Publisher	Tulane University
Publication Date	2003
Source	116 p., Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2080
Identifier	See 'reference url' on the navigation bar.
Rights	Copyright is in accordance with U.S. Copyright law
Contact Information	digitallibrary@tulane.edu
Rating

Find results with:

Searching collections:

Home Model selection and optimization of the sodium ion channel through the use of single and ensemble...

Model selection and optimization of the sodium ion channel through the use of single and ensemble pulse protocols

Description

Tags

Comments