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Home Simulating the Affects of Glutamatergic Afferents on the Firing Pattern of Midbrain Dopamine...

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Simulating the Affects of Glutamatergic Afferents on the Firing Pattern of Midbrain Dopamine Neurons

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Contact Information	Please send any questions regarding this item to libref@uno.edu
Title	Simulating the Affects of Glutamatergic Afferents on the Firing Pattern of Midbrain Dopamine Neurons
Author	Landry Jr., Richard Spencer
Document Type	Master's Thesis
Keywords	DA neurons; Single spike firing and burst firing; Apamin; Bursting rate
Abstract	A computational model of a midbrain dopamine neuron was extended in this study to include a response to random excitatory afferent input by incorporating the receptor components AMPA and NMDA. In a diagonal band where average glutamatergic and tonic gabaergic input is roughly balanced, both single spike firing and bursting can be observed. Simulated SK channel block strengthens the correlation between pattern and rate and increases the number of spikes fired in bursts by increasing the spikes per burst. A simulated doubling of the AMPA/NMDA ratio leads to a frequency increase that becomes more prominent at high firing rates, and an increase in the percent spikes fired in bursts. Changes in pattern and rate are poorly correlated in the model. Manipulations of the neuron greatly depend on the background level of synaptic inputs, suggesting that interpretation of population data from dopamine neurons requires taking variability into account rather than averages.
Access	Unrestricted
Degree	M.S.
Degree Program	Applied Physics
Department	Dept. of Physics
Major Professor	Canavier, Carmen
Advisory Committee	Puri, Ashok; Hegseth, John; Murphy, John
Date Degree Awarded	2006-01-20; *
Format	PDF
URL	See 'reference url' on top or bottom navigation bars.
Relation	http://louisdl.louislibraries.org/NOD/Pages/home.php
Rights	The University of New Orleans and its agents retain the non-exclusive license to archive and make accessible this dissertation or thesis in whole or in part in all forms of media, now or hereafter known. The author retains all other ownership rights to the copyright of the thesis or dissertation.
Catalog Date	2006-09-27; *
Object File Name	nd000289
Viewer Information	Adobe Reader required for viewing (http://www.adobe.com/products/acrobat/readermain.html)
File Size	783.52 KB
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Simulating the Affects of Glutamatergic Afferents on the Firing Pattern of Midbrain Dopamine Neurons

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